Managing coronary artery disease in patients with atrial fibrillation just got a bit more clear when it comes to anti-thrombotic therapy.

A systematic review and meta-analysis led by Hurley resident physician Srikanth Malladi MD reviewed scientific literature - including new randomized control trials - to evaluate the effects of oral anticoagulation on patient outcomes. The review article was published in the Dec. 3, 2021, online edition of Medicine, Vol 100, Issue 48, p 327498.

The authors' conclusion found no reduction of major adverse cardiac events in combination therapy and in monotherapy, so current recommended treatment guidelines are still valid.

The complete citation:

Malladi S, Hamid K, Pendyala NC, Veerapaneni V, Deliwala S, Dubre D, Elian SA, Singh A. Management of stable coronary artery disease and atrial fibrillation with anti-thrombotic therapy: a systematic review and meta-analysis. Medicine. 2021;100:48(e27498).

About the authors

• Malladi is a fourth-year resident in Hurley's Combined Internal Medicine/Pediatrics Residency Program, where he serves as chief resident in charge of quality and patient safety and didactics.
• Hamid is a graduate from Hurley's Combined Medicine/Pediatrics program and is now in the Division of Pulmonary / Critical Care, University of South Alabama College of Medicine, Mobile, Ala.
• Pendyala is from the Internal Medicine Department at Coney Island Hospital, Brooklyn, N.Y.
• Veerapenini and Deliwala are from the Internal Medicine Department at Hurley Medical Center.
• Dubre is an alumnus and was a faculty member in Hurley's Combined Medicine/Pediatrics program at the time that he coauthored this paper.
• Elian is from the Division of Cardiology at Hurley Medical Center/Michigan State University, where he is a faculty member.
• Singh is program director of the Hurley Combined Med/Peds Residency Program.